Ebola
Studies show that survivors of Ebola virus infection have antibodies proteins made by the immune system that identify and neutralize invading viruses that can be detected in the blood up to 10 years after recovery. Ebola virus can hide in the brain and cause infection later.
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. Survivors are thought to have some protective immunity to the type of Ebola that sickened them. For both COVID-19 and Ebola significant discordance between the robust preclinical data and remdesivirs lackluster clinical performance have left many puzzled. Here we critically evaluate the assumptions of the models underlying remdesivirs promising preclinical data and show that such assumptions overpredict efficacy and minimize toxicity.
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